Assessment of expression of genes associated with inflammation revealed fetuin-A-dependent upregulation of TBX21 (a Th1 cell-specific transcription factor) in the lungs of Cm-infected WT mice that correlated with IFN- γ induction. Importantly, the observed increased IFN- γ production was abrogated in fetuin-A-deficient AHSG mice suggesting that IFN- γ induction following Cm infection is fetuin-A dependent. We report here that in wild-type mice 12 days after Chlamydia muridarum (Cm) intranasal challenge, fetuin-A content in the lungs decreased 46%, while INF- γ increased 44%, consistent with a negative regulatory role of fetuin-A in inflammation. To check, load up the game and select Game Options, click Game Settings and make sure Save Compressed is set to No.Fetuin-A is an acute phase glycoprotein shown to counter in a regulatory manner proinflammatory cytokine production to maintain homeostasis during inflammation. In order for CM Explorer to work, your saved games will need to be in uncompressed mode.

Run CMExplorer, open your saved game and away you go! Add a Windows-explorer like interface ensuring using the editor is a trouble-free experience and you probably have one of the most complete packages to appear for CM 01/02.ĭownload from the above link and extract to anywhere on your computer. The saved game editor functions as a real-time saved game editor which means that you can run the editor and your CM 01/02 saved game simultaneously with the changes done via the editor taking immedeate effect.

Scout the entire database for items with given characteristics with the help of filters.įind players and staff with best ratings with the help of the rating sorting capability.Ĭonvenient browsing of the entire database. With the help of CMExplorer one can accomplish the following tasks:Īdd, delete, and edit players, including editing player contracts and injuries in saved games.Īdd, delete, and edit clubs, including editing club cash in saved games.Įdit names to resolve name generation problems. If that weren't enough, the utility also has a scout editor available to be used that has numerous filters available to ensure your scouting is successful. What sets CM Explorer apart from probably every other saved game editor is the fact that it has secondary functionality as a pre-game editor. CM Explorer allows you to basically edit everything in your save game bar player histories.

Cm 01 02 real time editor